CHO Cell line development
GTP Bioways offers SMART cell line development services to provide you with highly producing and stable mammalian cell lines ready for transfer to GMP manufacturing.
GMP-compliant mammalian cell line development service
We know how fundamental is the cell line development step for the successful development of your biotherapeutic candidate.
Our SMART CHO cell line development service is very well adapted to biopharma companies with challenging molecules looking for a partner offering expertise, flexibility and guidance.
We offer services from synthesis to the generation of a stable and thoroughly characterised Research Cell Bank (RCB). Our unique tailored approach for cell line development includes product quality analysis at key points during clone selection, ensuring both product critical quality attributes and productivity targets are met.
Efficient workflow for accelerated CHO cell line development
With a well-established workflow for the cloning, transfection and selection of the top clones, we are able to offer competitive timelines.
Our 2-step process includes a first selection of top parental clones followed by a limiting dilution with the help of a high-resolution imaging system.
In addition to providing an increased assurance of clonality, this process means we can, starting from the parental clones, offer an early preparation of non-GMP materials and accelerate process development for projects with strict time constraints.
Efficient and recognised CHO platform
GTP Bioways’ cell line development services rely on the CHOvolution™ technology, an established, robust and highly performant CHO platform.
The technology is based on a non-genetically modified CHO-K1 host cell line with a proprietary vector system which ensures the insertion of at least two copies of the expression cassette into the genome. Together with the use of a strong promoter, this guarantees a strong expression of the gene of interest.
Are you looking to develop a CHO cell line for further GMP manufacturing of your antibody or protein candidate?
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